Antifungal drugs target the enzymes that make cell walls, so that fungi die by shriveling, exploding or not being able to grow.
UnverifiedContext
Expanding further on the finding, Gifford said, "This study had a number of surprising elements. First, we did not identify any of the DNA mutations that we might have expected. Antifungal drugs target the enzymes that make cell walls, so that fungi die by shriveling, exploding or not being able to grow. Somehow, these fungi had survived antifungal drugs, and we needed to find out why.
Evidence
www.nature.com · context
All four species are resistant to antifungal drugs, and the Y132F mutation in the azole drug target ERG11, previously described in C. auris, and was also detected in C. pseudohaemulonii.
History
- · Unverified · initial